Nerve injuries, which are very common around the world, have dramatic effects on life quality of the patients. There is a great need for alternative and innovative regenerative approaches, since a very limited level of regeneration can be achieved with current therapies. In the field of nerve tissue engineering, intensive efforts are being made to develop biocompatible and conductive nerve guidance channels with topography that can guide the linear orientation of damaged axons. The aim of this study is to develop hybrid SF/PLGA film scaffolds with nano-channeled topography and decorated with quercetin-conjugated gold nanoparticles (AuNP-Q) and to investigate the behavior of DRG (dorsal root ganglion) sensory neurons primarily isolated from the mice on these materials. The using hybrid film scaffold increased the physical and mechanical properties of the material. The laminin coating promoted the cellular adhesion and growth. Nano-channeled scaffolds modified with nanoparticles (SF/PLGA G0.5-AuNP83-Q) highly promoted the axonal orientation. It was evaluated that the developed biomaterial could help the orientation of cellular neurites/axons and support regeneration after implantation in a nerve injury site, within the scope of potential in vivo nerve tissue engineering studies.
@article{2024,title={Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons},abstractNode={Nerve injuries, which are very common around the world, have dramatic effects on life quality of the patients. There is a great need for alternative and innovative regenerative approaches, since a very limited level of regeneration can be achieved with current therapies. In the field of nerve tissue engineering, intensive efforts are being made to develop biocompatible and conductive nerve guidance channels with topography that can guide the linear orientation of damaged axons. The aim of this study is to develop hybrid SF/PLGA film scaffolds with nano-channeled topography and decorated with quercetin-conjugated gold nanoparticles (AuNP-Q) and to investigate the behavior of DRG (dorsal root ganglion) sensory neurons primarily isolated from the mice on these materials. The using hybrid film scaffold increased the physical and mechanical properties of the material. The laminin coating promoted the cellular adhesion and growth. Nano-channeled scaffolds modified with nanoparticles (SF/PLGA G0.5-AuNP83-Q) highly promoted the axonal orientation. It was evaluated that the developed biomaterial could help the orientation of cellular neurites/axons and support regeneration after implantation in a nerve injury site, within the scope of potential in vivo nerve tissue engineering studies. },author={İlyas Özçiçek-İlyas Özçiçek },year={2024},journal={European Journal of Science and Technology}}
İlyas Özçiçek-İlyas Özçiçek . 2024 . Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons . European Journal of Science and Technology.DOI:10.5281/zenodo.14180012
İlyas Özçiçek-İlyas Özçiçek .(2024).Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons.European Journal of Science and Technology
İlyas Özçiçek-İlyas Özçiçek ,"Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons" , European Journal of Science and Technology (2024)
İlyas Özçiçek-İlyas Özçiçek . 2024 . Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons . European Journal of Science and Technology . 2024. DOI:10.5281/zenodo.14180012
İlyas Özçiçek-İlyas Özçiçek .Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons. European Journal of Science and Technology (2024)
İlyas Özçiçek-İlyas Özçiçek .Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons. European Journal of Science and Technology (2024)
Format:
İlyas Özçiçek-İlyas Özçiçek . (2024) .Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons European Journal of Science and Technology
İlyas Özçiçek-İlyas Özçiçek . Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons . European Journal of Science and Technology . 2024 doi:10.5281/zenodo.14180012
İlyas Özçiçek-İlyas Özçiçek ."Design of Gold Nanoparticle/quercetin Modified, and Nano-channeled SF/PLGA Film Scaffolds for the Oriented Growth of Sensory Neurons",European Journal of Science and Technology(2024)
